In patients of a solid organ transplant, the chronic use of immunosuppressive agents to prevent allograft rejection, especially calcineurin inhibitors (CNIs), increases the long-term risk of malignancy compared with that of the general population. Because of the risk factors that may lead to malignancy some preventive measures can be taken in order to avoid this outcome. In this way, a careful screening of the donor and the patient can be used before transplantation, in addition to protective measures from sun exposure or other forms of radiation, vaccination against HPV in patients with age indication and mainly avoid excess immunosuppression. Thus, immunosuppression should be used strategically to obtain target values and avoid toxicity.

The weighting of risks and benefits is, perhaps, the core of clinical medicine and this practice becomes progressively refined as the repertoire of medical science grows. It is, then, indispensable that, for exemple, the protocols for cancer screening keep up with this growth in the best interest of patients. Once imunnosupression is imperative for transplant recipients, it is also imperative that its implications in cancer risks are taken in consideration. Fortunatly, as reported in this article, different medical societies are already starting to recommend specific screening protocols for specific kinds of transplant recipients.

it´s really interesting that the article brings up the fact thet kidney transplant recipients are, indeed, more likely to develop cancer, needing a more careful follow up and sometimes screening. This strongly suggests, therefore, that physicians should be as concerned by that as they are regarding the cardiovascular risks that are higher in this population too.

We learn in our classes the importance of patient autonomy and a shared decision between doctor and patient. We cannot expect, however, that this decision will be taken without adequate information on all the processes involved. The Anticancer Tutorial is an innovative tool because it provides, in an accessible and didactic way, the necessary information for the active participation of the patient in his healing process.

Transplanted patients are provided with individualized care that must be maintained throughout their lives. Thus, associating this with the increased risk of developing cancer should be a factor to be widely discussed, given the whole scenario already evidenced. Patients should primarily be informed about possible complications, so that the decision is consistent with their judgment.

Patients with renal failure benefit from kidney transplantation, and have a better quality of life and survival compared to patients who need dialysis, however they must remain immunosuppressed until the end of life to maintain the function of the new kidney and this predisposes to neoplasms. Studies have shown an increase in cancer in patients with chronic kidney disease and also in kidney dialysis patients, so kidney transplant recipients should be monitored to avoid rejection, graft failure, cancer and death. The cause of oncogenesis is given by the suppression of the immune system, which can allow viral reapplication, new oncogenic pathways downstream, leading to Kaposi's Sarcoma, lymphoproliferative diseases, hepatocellular carcinoma, and lip and anal cancer. For this reason, we must research drugs that allow immunosuppression but that are not oncogenic.

Cancer is an important outcome after kidney transplantation because it is the second leading cause of death in most Western countries and represents a rapidly growing public health problem. The increased risk of cancer in transplant recipients is multifactorial and attributed to oncogenic viruses, immunosuppression and altered T-cell immunity. In view of the presented scenario, it is relevant to adapt, in a personalized way, the process of evaluation of the transplanted patient, from effective strategies for cancer screening after kidney transplantation and treatment, considering the individual's risk of cancer, the comorbidities, general prognosis and patient preferences. It is essential that the patient has knowledge and education about cancer risk in the context of transplantation.

Imunosupression is a hallmark of transplanted patients, given that a weakened immune system provides less protection against the growth of tumors. Hence, the medical establishment has been faced with a decisive conundrum: how to decide when the benefits outweight the risks, that is, how to assess the viability of a transplantation in every specific instance, taking into consideration the higher propensity for oncogenesis allied with other factors, such as comorbidities and the affected individual's personal values and wishes.

Although imunosupression is a crucial intervention to the success of the kidney transplant, it has a huge oncogenic potencial. Therefore, physisians must be aware of the risk transplanted patients are exposed to and should engage in different cancer tracking strategies. Combined with good medical practice, it is possible to enable CKD patients to appreciate the best medical treatment with less harm.

Immunosuppression is an indispensable intervention with regard to kidney transplants, as it reduces the chances of graft rejection. Nevertheless, using immunosuppressants can lead to severe outcomes, cancer being an example, as it reduces the capacity of the body to respond properly to procarcinogenic metabolism. Because of this panorama, the medical follow-up and the monitorization of these patients must be emphatic and a priority, especially considering the prevalent types of cancer in this population. Therefore, more studies are needed to properly track the disease in these patients and build adequate guidelines for this purpose.

Unfortunately, the imunossupression that comes with kidney transplantation increases the risk of cancer development. That said, kidney transplant patients should be informed about this fact, health professionals should be aware and screening tests should be made when considered appropriate.

It's amazing how much kidney transplantation has led to increased survival of patients with CKD, but the challenges don't stop, considering the increased risk of cancer due to immunosuppression. Although renal cancer screening is not cost-effective for everyone, it can be an extremely beneficial decision for the health of certain patients with major risk factors.

Patients who have had a kidney transplant are on immunosuppressive treatment for the rest of their lives, which increases the risk of oncogenesis. Therefore, the risks and possible complications should be discussed with the patient when making decisions about whether or not to perform a screening.

The life of the renal transplant patient has improved in relation to the patient who undergoes dialysis, a burden is that they need to be immunosuppressed to avoid rejection of the transplanted organ. There has been an increase in the incidence of cancer in kidney transplant recipients, for this reason the transplanted patient must be monitored and screened for cancer.

Considering that transplantation is the most effective intervention to reduce morbidity and mortality in CKD patients, it is unfortunate that transplantation-related immunosuppression results in an increase in malignancy in these patients. In view of this, strategies for early detection of the tumor in transplanted patients are necessary. Furthermore, these patients should be aware of the risks and complications of transplantation.

This text highlights the increased risk of cancer in kidney transplant recipients due to immunosuppression. Although kidney transplantation is a cost-effective intervention that improves the quality of life and overall survival of patients, patients must remain immunosuppressed for life to maintain allograft function, which increases their risk of cancer. The most common cancers associated with immunosuppression include kidney and urothelial cancers, Kaposi's sarcoma, lymphoproliferative diseases, and skin cancer. The use of mTOR inhibitors may have potential antitumor effects and is recommended for patients with early and moderate-stage tumors. While cancer screening for kidney transplant recipients is not yet based on prospective randomized trials, some personalized guidelines have been suggested by American and European transplantation societies. Overall, shared decision-making should be employed when conducting cancer screening for kidney transplant recipients.

The article addresses a crucial issue for the health of kidney transplant recipients: the risk of developing cancer. Among the main types are skin and lung neoplasms and lymphomas. This is a very interesting and practical topic, since in the nephrology and dermatology outpatient clinics of the HCPA, for example, it is common to see such cases. For this reason, it is necessary to encourage the screening and early detection of these diseases, so that the resolution of one disease does not lead to the formation of another that can be even more serious for the patient.